#3133
Establishment of neuroendocrine neoplasms organoid biobank enables genotype-phenotype mapping
Introduction:
Gastroentero-pancreatic (GEP) neuroendocrine neoplasm (NEN) that consists of neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC) is a lethal but under-investigated disease owing to its rarity. Incidence of this disease is recently increasing, and novel treatment is warranted. However, the establishment and application of GEP-NEN disease models have been limited.
Conference:
18th Annual ENETS Concerence (2021)
Presenting Author:
Authors:
Kawasaki K,
Fujii M,
Kudo A,
Kanai T,
Nakagawa H,
Keywords:
organoids,
CRISPR-Cas9,
multi-omics analysis,
gastrinoma,
MiNEN,
#3047
Functional Consequence of β-Arrestin 1 Gene Knock-Out in Pancreatic Neuroendocrine Tumor Cell Line BON-1
Introduction:
An important limiting factor influencing treatment efficacy of neuroendocrine tumors (NETs) with somatostatin analogs (SSA) is the availability of somatostatin receptors (SSTR) on NETs. While downregulation or altered pattern of SSTR expression are important considerations, receptor internalization/desensitization by β-arrestins may be a crucial contributing factor. Interestingly, our previous study showed a preferential higher expression of β-arrestin 1 (ARRB1), in gastroenteropancreatic NETS (GEP-NETs) compared to pituitary adenomas.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Iyer A
Authors:
Iyer A,
Vriens J,
Dogan-Oruç F,
van Koetsveld P,
Hofland L,
Keywords:
β-arrestin 1,
CRISPR-Cas9,
BON-1,
knock-out,
SSTR,
SSA,
Pan-NET,
