Abstract Library

#585 Global microRNA profiling of small intestine neuroendocrine tumors (SI-NETs) and establishment of a method to study serum microRNA expression from the same tumors

Introduction: MicroRNAs (miRNAs) are important post-transcriptional regulatorsin biological processes and function either as tumor suppressors or oncogenes.

Conference:

Presenting Author:

Authors: Li S, Martijn C, Essaghir A, Lloyd R, Demoulin J,

Keywords: small-intestine neuroendocrine-tumors, microRNA profiling, serum-miRNA expression,

#424 Role of MicroRNAs in Small Intestine Neuroendocrine Tumors

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) arise from enterochromaffin cells, which belong to the endocrine system. MicroRNAs (miRs) are post-transcriptional regulators. They control multiple biological processes often functioning either as tumor suppressor genes or oncogenes.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Li S, Martijn C, Essaghir A, Lloyd R, Demoulin J,

Keywords: small intestine, neuroendocrine tumors, microRNA profiling ,

#355 MicroRNA Signatures as Novel Biomarkers in Small Intestine Neuroendocrine Tumors

Introduction: Small intestine (SI) neuroendocrine tumors (NET) arise from serotonin-producing intraepithelial cells in the SI referred to as enterochromafin cells. The detection of SI-NETs is often concomitant with the appearance of hepatic metastasis thus most patients with SI-NET have metastases at initial presentation. MicroRNAs (miRs) are post-transcriptional key regulators in tumorigenesis which regulate expression of other genes. Little evidence of miR expression or deregulation in SI-NETs has been reported.

Conference:

Presenting Author:

Authors: Li S, Ahmed E, Martijn C, Lloyd R, Demoulin J,

Keywords: Small intestine neuroendocrine tumors, laser microdissection, microRNA array, micro RNA targets. ,

#200 Genome-Wide MicroRNA Expression in Small Intestine Neuroendocrine Tumors (“Midgut carcinoids”): Upregulation of miRNA-182, miRNA-183 and Downregulation of miRNA-215

Introduction: MicroRNAs (miRs) may regulate cell proliferation, differentiation, apoptosis and function as tumor suppressors or oncogenes. MiR expression is not characterized in neuroendocrine midgut carcinoids.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Li S, Essaghir A, Martijn C, Lloyd R, Demoulin J,

Keywords: midgut specimens, microdissected normal enterochromaffin cells, Affymetrix, microRNA expression,