Abstract Library

#4129 Validation of a radiomics model to predict symptoms complications from small intestinal NET mesenteric metastases – Preliminary report

Introduction: The development of mesenteric metastases and associated mesenteric fibrosis in small intestinal neuroendocrine tumors (SI-NET) can cause significant complications and have implications in patients’ survival. CT is suboptimal for accurate assessment of the degree of fibrosis and prediction of complications. A better model is needed, therefore, in order to select patients who may benefit from a prophylactic surgical approach in the mesentery. Recently the promising role of a radiomics model was shown as a predictive tool for development of complications of mesenteric metastases/fibrosis in 68 patients.

Conference:

Presenting Author:

Authors: von Stempel C, Blazevic A, Starmans M, d' Afflitto M, de Herder W,

Keywords: small intestinal neuroendocrine tumor, mesenteric fibrosis, complications, radiomics,

#2995 Prediction of Symptomatic Mesenteric Mass in Patients with Small Intestinal Neuroendocrine Tumors Using a CT Radiomics Approach

Introduction: A mesenteric mass surrounded by fibrosis is a hallmark feature of small intestinal neuroendocrine tumors (SI-NETs) that can induce severe abdominal complications. To improve clinical outcome, there is a need for personalized treatment strategies based on accurate prediction of development of abdominal complications.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Blazevic A

Authors: Blazevic A, Starman M, Brabander T, Hofland J, Franssen G,

Keywords: Small-intestinal neuroendocrine tumors, mesenteric mass, mesenteric fibrosis, radiomics, CT scan,

#1679 Management of Neuroendocrine Tumors in the Netherlands

Introduction: To determine optimal management of patients with pancreatic neuroendocrine tumors (pNETs), more insight in the prognosis and treatment outcomes is needed.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Genc C

Authors: Genc C, Mackay T, Van Oijen M, Klümpen H, Nieveen van Dijkum E,

Keywords: pNET, Netherlands, management, national registry,

#1150 Platelet Serotonin But Not Dopamine Concentrations Are Lower in Pancreatic Neuroendocrine Tumor and Renal Cell Carcinoma Patients Compared to Healthy Individuals.

Introduction: Platelets carry VEGF-A, serotonin and dopamine. Serotonin stimulates and dopamine inhibits tumor angiogenesis. We hypothesized that platelets are activated in tumor vasculature and release angiogenic factors, resulting in lower platelet serotonin and dopamine.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Peters M, Van Faassen M, Van Asselt S, Bouma G, Meijer C,

Keywords: Serotonin, dopamine, pancreatic neuroendocrine tumor, renal cell carcinoma.,

#1099 Niacin (vitamin B3) Suppletion in Patients with Serotonin Producing Neuroendocrine Tumors

Introduction: Tryptophan is the precursor of serotonin and niacin (vitamin B3), critical for normal cellular metabolism. Tryptophan and niacin can be deficient in patients with serotonin producing neuroendocrine tumors (NETs). Niacin deficiency can lead to symptoms including pellagra.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Walenkamp A

Authors: Bouma G, Van Faassen M, Kats-Ugurlu G, De Vries E, Kema I,

Keywords: NET, Serotonin, Niacin, N1-methylnicotinamide.,