Abstract Library

#4623 [68Ga]Ga-DOTA-Exendin-4 PET/CT for the localisation of insulinoma: Results of an international, dual-centre, retrospective, open-label real-world imaging study

Introduction: Benign insulinomas are the main cause of endogenous hyperinsulinemic hypoglycaemia (EHH) in adults, with surgery as the only cure. Pancreas-preserving procedures are preferred, making precise localisation crucial. Recent studies indicate that GLP-1R imaging, such as [68Ga]Ga-DOTA-exendin-4 (68Ga-Ex4) PET/CT, outperforms conventional imaging in identifying insulinomas.

Conference:

Presenting Author: Fricke J

Authors: Fricke J, Laubner K, Schildmeijer M, Menz L, Christ E,

Keywords: GLP1-Receptor PET/CT, Insulinoma, nesidioblatosis, endogenous hyperinsulinemic hypoglycaemia, real-life data,

#1917 Clinical Correlates of Discrepant Results of Chromogranin a versus Serotonin Markers in Patients with Neuroendocrine Tumors

Introduction: Neuroendocrine tumors lead to elevated chromogranin A levels and elevated serotonin markers (urinary 5HIAA and platelet serotonin). These markers are employed for diagnosis and monitoring.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Meijer W

Authors: Meijer W, Bruikman C, Beukeveld G,

Keywords: neuroendocrine tumors, chromogranin A, urinary 5HIAA, platelet serotonin,

#1517 Additional Value for Urinary 5-Hydroxyindoleacetic Acid as Prognostic Marker in Neuroendocrine Tumors?

Introduction: 5-Hydroxyindoleacetic Acid (5-HIAA) is of value for diagnosis of NETs and correlates with severity of carcinoid syndrome. However its value for determining prognosis is uncertain, particularly in combination with other biomarkers

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Zandee W

Authors: Zandee W, Kamp K, Van Adrichem R, Feelders R, De Herder W,

Keywords: prognosis 5-HIAA,

#1150 Platelet Serotonin But Not Dopamine Concentrations Are Lower in Pancreatic Neuroendocrine Tumor and Renal Cell Carcinoma Patients Compared to Healthy Individuals.

Introduction: Platelets carry VEGF-A, serotonin and dopamine. Serotonin stimulates and dopamine inhibits tumor angiogenesis. We hypothesized that platelets are activated in tumor vasculature and release angiogenic factors, resulting in lower platelet serotonin and dopamine.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Peters M, Van Faassen M, Van Asselt S, Bouma G, Meijer C,

Keywords: Serotonin, dopamine, pancreatic neuroendocrine tumor, renal cell carcinoma.,