Global microRNA profiling of small intestine neuroendocrine tumors (SI-NETs) and establishment of a method to study serum microRNA expression from the same tumors
Introduction: MicroRNAs (miRNAs) are important post-transcriptional regulatorsin biological processes and function either as tumor suppressors or oncogenes.
Aim(s): To provide exclusive miRNAs profile and identify serum miRNA expression from SI-NET patients’ serum.
Materials and methods: We used frozen SI-NET specimens to perform Affymetrix miRNA-arrays. QRT-PCR analysis validated our in silico results. Moreover, human NET cells and serum samples were involved in the study.
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