Global microRNA profiling of small intestine neuroendocrine tumors (SI-NETs) and establishment of a method to study serum microRNA expression from the same tumors

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Introduction: MicroRNAs (miRNAs) are important post-transcriptional regulatorsin biological processes and function either as tumor suppressors or oncogenes.

Aim(s): To provide exclusive miRNAs profile and identify serum miRNA expression from SI-NET patients’ serum.

Materials and methods: We used frozen SI-NET specimens to perform Affymetrix miRNA-arrays. QRT-PCR analysis validated our in silico results. Moreover, human NET cells and serum samples were involved in the study.

Conference:

Presenting Author:

Authors: Li S, Martijn C, Essaghir A, Lloyd R, Demoulin J,

Keywords: small-intestine neuroendocrine-tumors, microRNA profiling, serum-miRNA expression,