Abstract Library

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ENETS Abstract Search

#3028 Pancreatic Neuroendocrine Neoplasms: Dissecting the Molecular Heterogeneity

Introduction: Pancreatic neuroendocrine neoplasms (PNENs) are a group of rare but biologically and clinically heterogeneous neoplasms with variable patient outcomes. Little is known about the molecular differences between PNENs and the biologic significance of such divergence.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Yang K, Kalloger S, Aird J, Lee M, Colborne S,

Keywords: Pancreatic neuroendocrine neoplasms, Exome, Transcriptome, Proteome,

#2974 MEK/RAF and PARP as Novel Targets in Neuroendocrine Neoplasms – First Results from a Molecular in vitro Tumor Board

Introduction: Neuroendocrine neoplasms (NEN) are a heterogeneous group comprising well differentiated neuroendocrine tumors (NET) and poorly differentiated neuroendocrine carcinomas (NEC). Although, major progress has been made in the development of targeted therapies in various cancers, establishment of a promising personalized therapy in NEN is still pending. So far, a lack of suitable preclinical models represent a major challenge concerning the validation of a mutational based targeted therapy (MBTT)

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Viol F, Sipos B, Amin T, Fahl M, Grabowski P,

Keywords: Neuroendocrine neoplasms, Personalized therapy, Preclinical in vitro models, Mutational based targeted therapy,

#2896 Comparative Genomic Analysis of High Grade Neuroendocrine Neoplasms across Diverse Organs

Introduction: Grade 3 neuroendocrine neoplasms (G3 NENs), if poorly differentiated, have a median survival of 10-19 months. Little is known regarding biologic differences between G3 NENs from different primary sites, most commonly GI and lung.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Sun T

Authors: Sun T, Van Hummelen P, Martin B, Xia C, Zhao L,

Keywords: grade 3, high grade, neuroendocrine carcinoma, whole exome sequencing, rna-seq, transcriptomics, copy number analysis, sequencing, genomics, poorly differentiated,

#2855 Whole Exome Sequencing Reveals the Monoclonal Origin of Gastric Mixed Adenoneuroendocrine Carcinomas

Introduction: Gastric mixed adenoneuroendocrine carcinomas (g-MANECs) are rare neoplasms consisting of adenocarcinoma and neuroendocrine neoplastic components. G-MANECs show more malignant characteristics than gastric adenocarcinomas, while molecular mechanisms underlying the co-existence of the two components remains unknown.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Yan S, Chen X, Zhang R, Song L, Yin F,

Keywords: whole exome sequencing, mixed adenoneuroendocrine carcinoma, Stomach, Evolution,

#2745 Integrative Genomic Characterization Identifies Molecular Subtypes of Lung Carcinoids

Introduction: Lung carcinoids (LCs) are rare and slow growing primary lung neuroendocrine tumors. The WHO classify LCs into atypical and typical carcinoids. Recent studies have shown that the reproducibility of LCs classification and its prognostic efficacy have high interobserver variability

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Laddha S

Authors: Laddha S, da Silva E, Robzyk K, Untch B, Ke H,

Keywords: MEN1, Lung Carcinoid, Lung Cancer, ASCL1, Novel Molecular Subtypes, Genotype to Phenotype, Integrative Genomic Analysis, Biomarkers, Genomics and Epigenomics,