Abstract Library

#2827 Characterization of Epigenetic Modulation in Pancreatic Neuroendocrine Neoplasms

Introduction: Pancreatic neuroendocrine tumors (PanNETs) represent a rare and heterogeneous tumor entity. Despite advances in therapy cancer progression and resistance mechanisms are still challenging. Recent genome wide sequencing analyses in PanNETs identified a large number of mutated genes involved in epigenetic modulation.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Schmitz R

Authors: Schmitz R, Weißbach J, Kleinlein J, Schrader J, Grabowski P,

Keywords: PanNET, HDAC-Inhibition, SOCS3, lncRNA, Macrophages,

#2684 Tumour-Infiltrating Neutrophils Predict Poor Survival of Non-Functional Pancreatic Neuroendocrine Tumour Patients after Curative Resection

Introduction: Non-functional pancreatic neuroendocrine tumours (NF-PanNETs) are steadily increasing in prevalence and present several clinical challenges.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Zhang W, Wang W,

Keywords: non-functional pancreatic neuroendocrine tumours, tumour immune microenvironment, tumour-infiltrating neutrophils, prognosis, predictors,

#1945 Metabolic Adaptation to Anti-Angiogenic Therapy

Introduction: Although anti-angiogenic inhibition (AI) therapy has demonstrable efficacy in mouse models of cancer and in certain types of human cancer, responses are typically transitory, followed by resumption of malignant progression that limits survival benefit. Unconventional modes of evasive/adaptive resistance underlay the eventual failures of anti-angiogenic therapy. Functionally established resistance mechanisms include revascularization mediated by alternative pro-angiogenic signals, protection by peri-vascular macrophages and monocytes to induce an immunosuppressive microenvironment, and normal vessel cooption via heightened local invasion and distant metastasis. All three mechanisms have been documented in the prototypical RIP-Tag2 mouse model of multistep tumorigenesis, in which the angiogenic switch is a discrete step in the pathway to invasive pancreatic neuroendocrine cancer.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Allen E

Authors: Allen E,

Keywords: AI/mTOR,

#1219 Changes in Neuroendocrine Tumor Microenvironment with WHO Tumor Grading

Introduction: The microenvironment of neuroendocrine neoplasias (NEN) in view of tumor grading (WHO classification of 2000 und 2010) has not yet been validated. Both classifications distinguish between well and poorly differentiated neuroendocrine tumors, including proliferation rate, mitotic index and histomorphology. The WHO classification of 2000 further evaluates tumor location, size, angioinvasion, invasion of the muscle layer, functionally active tumors and metastases.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Cameron S

Authors: Cameron S, Skupin J, Füzesi L,

Keywords: NEN stroma,

#1066 The Impact of Pharmacological-Mediated Depletion of Macrophages in Pancreatic Neuroendocrine Neoplasms

Introduction: Pancreatic neuroendocrine tumors (PNETs) are a heterogeneous group of neuroendocrine neoplasms with distinct biological behaviour and response to treatment. Previous reports indicate that the infiltration of tumor-associated macrophages (TAMs) in PNETs strongly correlates with proliferation and metastases.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Krug S

Authors: Krug S, Abbassi R, Rinke A, Griesmann H, Gress T,

Keywords: clodro, TAM, RIP1-Tag2,