Abstract Library

#3974 Small extracellular vesicles miR-183-5p derived from highly invasive pancreatic neuroendocrine tumors reprogram macrophages towards SPP1+ macrophages

Introduction: Highly-metastatic (HM) pancreatic neuroendocrine tumors (pNETs) are characterized by an early occurrence of lymph node and liver metastases and a poor prognosis. Single-cell sequencing analysis showed that HM pNETs had remarkable infiltration of SPP1+ macrophages, which were involved in cell migration, angiogenesis and small extracellular vesicles (sEVs).

Conference:

Presenting Author:

Authors: Zhang W, Xu J, Lou X, Qin Y, Chen J,

Keywords: pancreatic neuroendocrine tumor, p53, small extracellular vesicles, macrophages, SPP1, biomarker,

#3622 Hypoxia down-regulates m6A methyltransferase METTL3 and WTAP promotes pancreatic neuroendocrine tumor metastasis via regulating TGFBI

Introduction: Hypoxia is a marker of cancer progression. When faced with hypoxia, tumor cells exhibit the dynamic change of N6-methyladenine (m6A). m6A is a reversible RNA modification that plays an important role in gene expression regulation and is closely related to the occurrence and development of various tumors.

Conference:

Presenting Author: Ye M

Authors: Ye M, Bai J, Tian Y, Chen J, Lu F,

Keywords: Pancreatic neuroendocrine tumor, RNA methyltransferase, exosomes, tumor-associated macrophages, tumor metastasis,

#3184 Immune heterogeneity and cascade of changes in subtypes of pancreatic neuroendocrine tumors

Introduction: Previously, we published four molecular subtypes of pancreatic neuroendocrine tumors (PanNETs) - met-like primary (MLP)-1 and -2, intermediate and insulinoma- like with different clinical and molecular characteristics. While immunotherapy trials are on-going in PanNETs, the immune landscape of this disease is largely unknown.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Sadanandam A

Authors: Sadanandam A, Young K, Lawlor R, Ragulan C, Patil Y,

Keywords: pancreatic neuroendocrine tumor, immune microenvironment, viral-mimicry pathway, pancreatic cancer, computational methods, T cells, macrophages, immunotherapy, B cells, complement pathway, interferon signalling, STING pathway, hypoxia, necroptosis, tumor ,

#2827 Characterization of Epigenetic Modulation in Pancreatic Neuroendocrine Neoplasms

Introduction: Pancreatic neuroendocrine tumors (PanNETs) represent a rare and heterogeneous tumor entity. Despite advances in therapy cancer progression and resistance mechanisms are still challenging. Recent genome wide sequencing analyses in PanNETs identified a large number of mutated genes involved in epigenetic modulation.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Schmitz R

Authors: Schmitz R, Weißbach J, Kleinlein J, Schrader J, Grabowski P,

Keywords: PanNET, HDAC-Inhibition, SOCS3, lncRNA, Macrophages,

#2684 Tumour-Infiltrating Neutrophils Predict Poor Survival of Non-Functional Pancreatic Neuroendocrine Tumour Patients after Curative Resection

Introduction: Non-functional pancreatic neuroendocrine tumours (NF-PanNETs) are steadily increasing in prevalence and present several clinical challenges.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Zhang W, Wang W,

Keywords: non-functional pancreatic neuroendocrine tumours, tumour immune microenvironment, tumour-infiltrating neutrophils, prognosis, predictors,