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#1119 Gly388Arg FGFR4 Polymorphysm is Not Predictive of Everolimus Efficacy in Gastrointestinal Well Differentiated Neuroendocrine Tumors (NET)

Introduction: Preclinical data suggest that single nucleotide polymorphism substituting an arginine (R) for glycine (G) in codon 388 of the FGFR4 transmembrane domain may increase proliferation of xenografted neuroendocrine cell lines and decrease their sensitivity to everolimus by modulating STAT3 signaling and the mTOR pathway.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Cros J

Authors: Cros J, Moati E, Raffenne J, Hentic O, Svrcek M,

Keywords: N,