Abstract Library

#4656 Development of a 3D patient-derived extracellular matrix hydrogel model of small intestinal neuroendocrine tumour and mesenteric fibrosis

Introduction: The pathogenesis of mesenteric fibrosis in small intestinal neuroendocrine tumours (SI-NETs) is poorly understood, limiting development of effective treatments and biomarkers. A major barrier to research is the lack of disease models.

Conference:

Presenting Author:

Authors: Hodgetts H, Martins M, Luong T, Hall A, Webster A,

Keywords: small intestine, neuroendocrine, 3D model, hydrogel, fibrosis,

#4647 Crosstalk between cancer-associated fibroblasts and small intestinal neuroendocrine tumour cells in a 3D spheroid model

Introduction: At diagnosis, over 50% of small intestinal neuroendocrine tumours (SI-NETs) have metastasised to the mesentery where they often induce extensive fibrosis. Recent studies highlight the crucial interaction between SI-NET cells and cancer-associated fibroblasts (CAFs) in the pathogenesis of mesenteric fibrosis (MF).

Conference:

Presenting Author:

Authors: van der Slik E, Feelders R, van Koetsveld P, Iyer A, Hofland J,

Keywords: mesenteric fibrosis, small intestinal neuroendocrine tumour, CAF,

#4227 Evaluation of circulating extracellular vesicles as suitable prognostic markers in MEN1-associated non-functioning pancreatic neuroendocrine neoplasia

Introduction: Non-functioning pancreatic neuroendocrine neoplasias (NF-pNENs) significantly contribute to premature death of multiple endocrine neoplasia type 1 (MEN1) patients. Reliable prognostic markers for disease progression are lacking. Circulating liquid biomarkers, including microRNAs and Long-non-Coding (LnC) RNAs in extracellular vesicles, are emerging as new prognostic tools.

Conference:

Presenting Author:

Authors: Manoharan J, Khizanishvili N, Krasser-Gercke N, Albers M, Mintziras I,

Keywords: Multiple endokrine neoplasia type 1, Extracellular vesicles, Non-functioning pancreatic neuroendocrine neoplasia, exosomal-LnC-RNA NEAT1, exosomal miRNA451a,

#4047 The role of adipocytes in neuroendocrine neoplasms: Molecular and metabolic adaptations

Introduction: It is recognized that the adipose tissue plays a major role in cancer. Recent evidence suggests the existence of altered metabolic pathways in neuroendocrine neoplasms (NENs), influencing tumor development and evolution, and thereby clinical outcomes.

Conference:

Presenting Author: Calabrese C

Authors: Calabrese C, Dellavalle S, Miserocchi G, Gabellone S, Spadazzi C,

Keywords: neuroendocrine neoplasm, adipocytes, metabolism, RNA-seq, 3D co-cultures,

#4011 Differences in the microRNA expression of G1 and G2 pancreatic neuroendocrine tumors

Introduction: Targeted testing of microRNAs implicated in the biology of pancreatic neuroendocrine tumors (PNET) was performed via RT-QPCR to uncover differentially expressed microRNAs that could be used as diagnostic markers characteristic for tumor grade.

Conference:

Presenting Author:

Authors: Nyirő G, Szeredás B, Vékony B, Borka K, Zalatnai A,

Keywords: miRNA expression, PNET G1 and G2, RT-QPCR, hsa-miR-130b-3p, hsa-miR-194-5p, hsa-miR-96-5p, hsa-miR-106b, FFPE tissue,