Abstract Library

#2187 Typical and Atypical Bronchial NETs with Advanced Disease: Incidence, Management and Survival

Introduction: Bronchial NETs are classified according to the 2004 WHO classification into typical, atypical and poorly differentiated. Typical and atypical tumours can develop metastatic disease (Stage IV) which requires careful management

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: McFadyen R

Authors: McFadyen R, Smith J, Diamantopoulos L, Caplin M, Toumpanakis C,

Keywords: typical, atypical, bronchial, ki-67,

#2129 Phosphohistone H3 (PHH3) Immunohistochemical Staining Outperforms Conventional H&E Mitotic Count in Classifying Pulmonary Carcinoids

Introduction: Pulmonary carcinoids (PC) are well-differentiated NETs and are classified as typical carcinoid (TC) and atypical carcinoid (AC). Despite the fact that TC and AC exhibit significant differences in patient survival, their classification depends on relatively subtle differences in mitotic count (MC). Although careful counting of mitotic figures (MF) is essential, it is a very subjective task, time-consuming and lacks of sensitivity and interobserver reproducibility, due to selection bias of the hot spots, heterogeneous distribution of MF, difficulty in distinguishing MF from similar chromatin changes (i.e. in apoptotic cells or due to crush, karyorrhectic debris, pyknosis or apoptosis).

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Luong T

Authors: Luong T, McCaughran W, Caplin M, Toumpanakis C, Thirlwell C,

Keywords: Phosphohistone H3, Pulmonary Carcinoids, Typical Carcinoid, Atypical Carcinoid, Mitotic Count, H&E,

#1796 Typical Bronchial Neuroendocrine Tumours with Advanced Disease: A Misleading Biology

Introduction: Bronchial NETs are graded by histological classification into ‘typical’, ‘atypical’ NETs or small and large neuroendocrine carcinoma’s. Typical NETs are regarded as being low-grade malignant however metastatic disease can still develop.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Diamantopoulos L

Authors: Diamantopoulos L, Demetriou G, Laskaratos F, Caplin M, Toumpanakis C,

Keywords: Bronchial, Typical,

#1698 Assessment of Small Intestinal Bacterial Overgrowth (SIBO) in NET Patients

Introduction: SIBO is not uncommon in NETs. Hydrogen Breath testing (HBT) using glucose may be more sensitive to proximal SIBO as glucose rarely reaches the colon. Many NET patients are likely to have distal SIBO however, as factors such as ileocecal valve removal apparently increase distal SIBO risk. Thus glucose BT alone may limit sensitivity for detecting SIBO in some NET diagnoses.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Whyand T, Koffas A, Toumpanakis C, Mandair D, Caplin M,

Keywords: nets, sibo, dysbiosis, ,

#1500 Analysis of Oesophageal Neuroendocrine Tumour Outcomes

Introduction: Oesophageal Neuroendocrine Tumours(NETs) are rare neoplasms accounting for <2% of Gastroenteropancreatic NET(GEP NETs).

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Koffas A

Authors: Koffas A, Watkins J, Mohmaduvesh M, Thirlwell C, Toumpanakis C,

Keywords: oesophageal nec,