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#3928 MEN1 deficiency-induced the activation of β-Catenin-MGMT axis promotes Pancreatic Neuroendocrine Tumor growth and disrupts the response to Temozolomide

Introduction: O6-methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the guanine O6 position (O6-MG) and repairs DNA damage. High MGMT expression results in poor response to temozolomide (TMZ).

Conference:

Presenting Author: Ji S

Authors: Ji S, Xu J, Wang F, Lou X, Ye Z,

Keywords: Pancreatic neuroendocrine tumor, MGMT, MEN1, Temozolomide tolerance,