Abstract Library

#743 In Vitro Anticancer Effect of Metformin on Neuroendocrine Tumor Cells

Introduction: Patients with multiple endocrine neoplasia (MEN) type 1 develop pancreatic NETs as well as bronchus carcinoids. No prophylactic drug is available yet. Metformin has been reported to act on the AMPK/mTOR signalling pathway and exhibit antitumoral activity in several cancer cell lines.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Vlotides G, Tanyeri A, Zitzmann K, Spampatti M, Spöttl G,

Keywords: neuroendocrine tumor, MEN-1, metformin,

#739 Aspirin Inhibits Cell Viability and mTOR Signalling in Neuroendocrine Tumor Cells

Introduction: Patients with multiple endocrine neoplasia (MEN) type 1 develop pancreatic NETs as well as thymic and bronchus carcinoids. Aspirin has been reported to inhibit mTOR signalling and exhibit antitumoral activity in colorectal cancer cells. So far, no data with aspirin on NETs have been published.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Spampatti M, Vlotides G, Spöttl G, Maurer J, Göke B,

Keywords: neuroendocrine tumor, MEN-1, aspirin, mTOR,