Abstract Library

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#3283 Tumor growth rate in well-differentiated G1-3 gastroenteropancreatic neuroendocrine tumors (GEP-NETs): Implications for clinical trials

Introduction: Drug development in G1-3 GEP-NETs is hampered by heterogeneous tumor biology and the cytostatic nature of most active agents. Optimal care of G3NETs is ill-defined, as recent phase 3 studies have not accounted for this group. Tumor growth rate (TGR) allows dynamic evaluation of growth and has prognostic value in G1-2; little is known about TGR in G3.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Wang S, Whitman J, Paciorek A, Le B, Zhang L,

Keywords: GEP-NET, tumor growth rate, Ki67,

#3256 Surgical outcomes in extrapulmonary G3 neuroendocrine neoplasms

Introduction: Incidence of high-grade neuroendocrine (NE) neoplasms (G3NENs) is increasing. Heterogeneity of these tumors (well-differentiated NE tumors, G3NETs; poorly differentiated NE carcinomas, NEC) presents obstacles to clinical management and role of surgery is uncertain. Majority of published data suggest benefit of surgery in NECs limited to localized disease. Role of surgery in G3NET remains ill-defined.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Lopez M

Authors: Lopez M, Whitman J, Le B, Paciorek A, Zhang L,

Keywords: resection, G3NET, differentiation, G3NEN,