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#1312 Epigenetic Remodeling upon DAXX and ATRX Loss in Pancreatic Neuro-endocrine tumors (pNETs)

Introduction: DAXX and or ATRX loss occur in 40% of sporadic pNETs. DAXX and ATRX participate in the cell epigenetic status maintenance. Epigenetic changes influence gene expression, function of telomeres and genomic stability. We hypothesize that DAXX/ATRX loss drives tumor progression in pNET through epigenetic changes affecting genomic stability.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Marinoni I, Wiederkeher A, Pantasis S, Normand L, Wiedmer T,

Keywords: DAXX/ATRX, epigenetic, CIN,