Abstract Library

#4007 Inactivation of PHLDA3 gene leading to tumorigenesis of pancreatic neuroendocrine tumors and its molecular mechanisms

Introduction: The molecular mechanism underlying the tumorigenesis of sporadic pancreatic neuroendocrine tumors (PNETs) is largely unknown. Our previous studies showed that loss of heterozygosity (LOH) at chromosome 1q31 (including PHLDA3 gene) was frequently found in sporadic PNETs (2005 insulinoma and 2003 gastrinoma, respectively).

Conference:

Presenting Author: Song Y

Authors: Song Y, Tong W, Wang Z, Chen Y,

Keywords: pancreatic neuroendocrine tumor, PHLDA3, tumorigenesis, prognosis,

#1346 A Nation-Wide Retrospective Epidemiological Study of Gastroenteropancreatic Neuroendocrine Neoplasms in China

Introduction: Representative data on the gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) in Chinese patients is rare.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Jin-Hu F, Yu-Qing Z, Su-Sheng S, Yuan-Jia C, Xing-Hua Y,

Keywords: gastroenteropancreatic neuroendocrine neoplasm, multi-center, retrospective study, epidemiology,

#413 Expression of UCH-L1 in PETs and its Implications

Introduction: There is a lack of reliable biomarkers to distinguish benign from malignancy in pancreatic endocrine tumors (PETs) and to predict prognosis. Our previous study on insulinoma found the expression of UCH-L1 in these tumors. The diagnostic or prognostic value of this protein has not been well demonstrated in PETs.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Chen Y, Qiao X, Tang L, Wan Y, Lu C,

Keywords: pet, UCH-L1, biomarker, diagnosis, prognosis,

#264 Alterations of TIMP-3 Gene in Insulinomas and Its Significance

Introduction: Our previous study on insulinoma found allelic loss of 22q12 where suppressor gene TIMP3 located. TIMP3 can inhibit tumor invasion or metastasis, but its clinical implications in insulinoma are unknown.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Chen Y, Zhou C, Wu H, Liu T, Xiao Y,

Keywords: insulinoma, TIMP-3 gene, allelic loss, biomarker,

#72 Reduced expression of p27 and the occurrence of CpG island methylator phenotype in insulinomas

Introduction: The molecular pathogenesis of sporadic insulinoma is unclear, though some of the genes were found to be slienced by promoter methylation. CpG island methylator phenotype (CIMP) was found in a number of common tumors and correlated with loss of expression of p27, which may contribute to the tumorigenesis of the tumors.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Chen Y

Authors: Chen Y, Zhou Q, Xiao Y, Zhu Y, Liu T,

Keywords: insulinoma, p27 gene, promoter methylation, CpG island methylator phenotype ,