Abstract Library

#4637 Non-functional retroperitoneal paraganglioma in a young patient: A case report

Introduction: Paragangliomas are neuroendocrine tumours arising in the parasympathetic nervous system, outside the adrenal gland. Retroperitoneal location is extremely rare. Non-functional paragangliomas often represent a diagnostic challenge.

Conference:

Presenting Author:

Authors: Aris H, Saidi M, Lahfa I,

Keywords: retroperitoneal paraganglioma, surgery, monitoring,

#4593 Excellent response to Ac-225 DOTATATE therapy in a patient with small cell lung cancer

Introduction: Peptide receptor radionuclide therapy (PRRT) is a validated treatment for patients with NETs overexpressing somatostatin receptors (SSTR). IHC analysis indicates that up to 50% of small cell lung cancer (SCLC) tumours are SSTR2 positive and thus can be targeted by SSR imaging and PRRT. Therapy with α-emitting radionuclides, such as Ac225, may offer several advantages over β-emitters by having higher energy transfer and more effective cancer cell death.

Conference:

Presenting Author: Tuncel M

Authors: Tuncel M, Türkan C, Eryılmaz Y, Pala A, Kılıçkap S,

Keywords: Ac-225 DOTATATE, Small Cell lung cancer, PET, somatostatin receptor, PRRT,

#4479 Bilateral adrenal masses associated with arterial hypertension with rare and unexpected definitive histopathological diagnosis: A case report

Introduction: During the clinical approach of bilateral adrenal masses, some imaging, biochemical and clinical guidelines are established to guide the diagnosis; however, only the histopathological result is what definitively establishes the diagnosis.

Conference:

Presenting Author: Rueda M

Authors: Rueda M, Cuellar A, Tapiero-Garcia M,

Keywords: adrenal gland, adrenal mass, Cystic lymphangioma, endothelial cyst, systemic arterial hypertension,

#4282 A first-in-human phase I trial with antibody drug conjugate ADCT-701 in neuroendocrine tumours and carcinomas

Introduction: Neuroendocrine neoplasms (NENs) consist of neuroendocrine tumours and neuroendocrine carcinomas, which are rare malignancies found in various anatomical sites, including the gastrointestinal tract, pancreatic islets, lungs, and adrenal glands. Poorly differentiated NECs are classified as high-grade carcinomas that bear resemblance to small-cell lung cancer; however, these patients experience a high risk of relapse and demonstrate a limited response to additional systemic therapies. Adrenocortical carcinoma (ACC) is another rare cancer and currently, no targeted therapies have demonstrated significant effectiveness for this condition. Preclinical investigations have indicated that Delta-like non-canonical notch ligand 1 (DLK1) is expressed in various neuroendocrine neoplasms, including ACC, SCLC, neuroblastoma, pheochromocytoma, and paraganglioma.

Conference:

Presenting Author: Del Rivero J

Authors: Del Rivero J, Glod J, Magee T, Cooper K, Rivero A,

Keywords: NEN, NEC, NET, ACC, ADC, ADCT-701,

#4170 Analysis of the efficacy of STEM chemotherapy in patients with metastatic paraganglioma

Introduction: Paraganglioma is a special kind of neuroendocrine tumor, located outside the adrenal gland, about 35-40% is related to heredity and has corresponding germline mutation. The therapeutic response is different from that of neuroendocrine tumors derived from gastrointestinal and pancreas.

Conference:

Presenting Author: Tan H

Authors: Tan H, Zhao H, Shi S, Jiang L, Chi Y,

Keywords: metastatic paraganglioma, STEM, efficacy,