Abstract Library

#1551 Establishment and Characterization of Three GEP-NEC Cell Lines for In Vitro and In Vivo Studies

Introduction: To date chemotherapeutic concepts applying cisplatin/etoposide for the treatment of highly aggressive GEP-NEC do not provide convincing results. Thus, there is an urgent need for NEC cell line models that provide a reliable experimental system in identifying novel therapeutic targets.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Krieg A

Authors: Krieg A, Riemer J, Dizdar L, Mersch S, Anlauf M,

Keywords: GEP-NEC,

#65 Deletions of 11q21-q25 are associated with atypical lung carcinoids and a poor clinical outcome

Introduction: Lung carcinoids comprise a group of smoking-unrelated neuroendocrine tumors, which can be classified in typical (TC) and atypical (AC) carcinoids. Classification is complex and its accuracy to predict disease outcome is variable. In a previous array comparative genomic hybridization (arrayCGH) study, we showed that the average number of chromosomal alterations (≥ 1Mb) was significantly higher in ACs than in TCs (512 v. 226 per tumor) and that the most common region of chromosome loss was 11q21-q25 (Neuroendocrinology 2009;90:136-137).

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Swarts D

Authors: Swarts D, Van Suylen R, Dingemans A, De Herder W, De Krijger R,

Keywords: pulmonary carcinoids, array CGH, survival, 11q deletion, prognosis,