Abstract Library

#2193 Advanced Gastric Neuroendocrine Carcinoma: A Diagnostic and Management Conundrum

Introduction: Gastric neuroendocrine carcinomas are rare tumors with a high malignant trait and poor prognosis. Endogenous hypercortisolism associated with neuroendocrine carcinomas can have a negative impact on patients' survival.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Lambrescu I, Martin S, Nitipir C, Terzea D, Cima L,

Keywords: gastric neuroendocrine carcinoma, hypercortisolism, Cushing disease, ectopic ACTH,

#1549 Ectopic Cushing Syndrome in a Patient with Metastatic Medullary Thyroid Carcinoma

Introduction: Ectopic Cushing syndrome was reported in 0.6% of patients with medullary thyroid carcinoma; it usually occurred in metastatic cases and significantly increases mortality.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Poiana C

Authors: Trifanescu R, Caragheorgheopol A, Schipor S, Dumitrascu A, Baciu I,

Keywords: Ectopic Cushing syndrome, medullary thyroid carcinoma,

#1426 Pseudotumor of Thymus Occuring After Hypercortisolism Recovery: Case Report

Introduction: Cushing syndrome is due to an ectopic secreting adrenocorticotropic hormone (ACTH) in 10 % to 20% of cases. Among them, thymic tumors represent almost half of cases. It has been described that patients sometimes develop benign hyperplasia after hypercortisolism correction.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Baki S, El Mghari G, El Ansari N,

Keywords: thymic tumor, Cushing's syndrome, ectopic secretion,

#1206 Two Cases of Ectopic ACTH-Secreting Neoplasm of Occult Origin Becoming Overt After Bilateral Adrenalectomy

Introduction: Cushing's syndrome (CS) is an endocrine disorder associated with serious consequences if not adequately treated. Nearly 80% of the cases of endogenous hypercortisolism are adrenocorticotropic hormone (ACTH) dependent, the ACTH source being pituitary in about 70-80% and ectopic in 10-15%. The ACTH source may remain occult in few cases for many years in spite of extensive investigations.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Piacentini S, Iacovazzo D, Lugli F, Giampietro A, Bianchi A,

Keywords: Cushing's syndrome, Ectopic ACTH, Bilateral adrenalectomy,

#1078 Somatostatin Responsive ACTH and Precursor Excess in a Midgut Mesentery NET

Introduction: ACTH production from a midgut mesentery NET is extremely rare (1). A 62y old woman presented with hypokalaemia (2mmol/L) and hyperpigmentation, 11y after surgery of a pT3N1Mx non-functional G1 NET with SRS positive, non-resectable but stable, residual mass encasing mesenteric vessels. Serum cortisol (3261 nmol/L), ACTH (796 ng/L), CgA (530 pmol/L) and urine total cortisol metabolites (33920 µg/24h) including 14 sub-products indicated change of biological behaviour into a functioning NET. Pituitary or pulmonary sources were excluded

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Weickert M, Khan S, Shatwell W, Chambers L, Tomkins C,

Keywords: NET, ACTH precursors, POMC, somatostatin,