Abstract Library

#4129 Validation of a radiomics model to predict symptoms complications from small intestinal NET mesenteric metastases – Preliminary report

Introduction: The development of mesenteric metastases and associated mesenteric fibrosis in small intestinal neuroendocrine tumors (SI-NET) can cause significant complications and have implications in patients’ survival. CT is suboptimal for accurate assessment of the degree of fibrosis and prediction of complications. A better model is needed, therefore, in order to select patients who may benefit from a prophylactic surgical approach in the mesentery. Recently the promising role of a radiomics model was shown as a predictive tool for development of complications of mesenteric metastases/fibrosis in 68 patients.

Conference:

Presenting Author:

Authors: von Stempel C, Blazevic A, Starmans M, d' Afflitto M, de Herder W,

Keywords: small intestinal neuroendocrine tumor, mesenteric fibrosis, complications, radiomics,

#3479 Mesenteric fibrosis in SI-NEN is characterized by strong dysregulation of CXCL9, IL6, COMP and COL6A6 genes

Introduction: Small intestine neuroendocrine neoplasms (SI-NENs) are characterized by the development of desmoplastic mesenteric fibrosis (MF) in up to 50 % of cases. This can cause intestinal obstruction and ischemia, which is a significant clinical problem.

Conference:

Presenting Author:

Authors: Graf S, Keber C, Hattesohl A, Denkert C, Di Fazio P,

Keywords: si-nen, si-net, comp, col6a6, cxcl9, il6, mesenteric fibrosis, desmoplasia, desmoplastic reaction, tumor microenvironment, tme, tumor stroma interaction, next generation sequencing, ngs, htg edgeseq, gene expression analysis, rna,

#1746 Clinical Outcomes in Small Neuroendocrine Tumours Treated with Intestinal Surgery in Tertiary Centre

Introduction: Patients with Small Bowel Neuroendocrine Tumours (SBNET) may require small bowel surgery either as an emergency or electively.Robust data from Tertiary Referral Centres (TRC) are lacking.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Demetriou G

Authors: Demetriou G, Crawford A, Guarino S, Ogunbiyi O, Varcada M,

Keywords: NET, intestinal surgery,

#1744 Predictors of Survival in Patients with Small Intestinal Neuroendocrine Tumours (SINETs) Associated with Mesenteric Desmoplasia

Introduction: SINETs represent 30-50% of small bowel neoplasms with a rising incidence and can be associated with mesenteric fibrosis (MF)

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Laskaratos F, Diamantopoulos L, Walker M, Khalifa M, Walton H,

Keywords: SINETs,

#984 Superior Mesenteric Vein Stenting for Management of Complications of Mesenteric Desmoplasia in Midgut Neuroendocrine Tumors

Introduction: Mesenteric fibrosis is a cause of morbidity and mortality in patients with midgut neuroendocrine tumors (mNETs). It may cause occlusion of the superior mesenteric vein (SMV), which can be associated with development ascites and mesenteric and small bowel varices (SBVs) leading to occult gastrointestinal (GI) bleeding.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Naik K, Rossi R, Toumpanakis C, Caplin M, Yu D,

Keywords: mesentetic desmoplasia, SMV, stent,