Abstract Library

#4423 Exploring decorin in plasma-derived small extracellular vesicles (sEVs) as a potential diagnostic biomarker for pancreatic neuroendocrine tumours

Introduction: Pancreatic Neuroendocrine tumours (PanNETs), the most common site for GEP‑NENs in Asian countries, particularly India, have shown increasing incidence. Due to a lack of specific biomarkers, often detected at advanced stages. So, this study utilised PanNET tissue proteomics for cancer biomarker discovery and explored the impact of small extracellular cellular vesicles (sEVs) in PanNET growth and metastasis, as they reflect the molecular profile of their tissue of origin.

Conference:

Presenting Author:

Authors: Gorai P, As S, Naik M, Kumar S, Pal S,

Keywords: Decorin, small extracellular vesicles, Pancreatic Neuroendocrine Tumour, Proteomics, circulating biomarker,

#4406 Fluorescence labelled plasma derived small extracellular vesicle as biomarkers in metastatic pancreatic neuroendocrine tumour patients

Introduction: Pancreatic neuroendocrine tumours (PanNET) are rare with increased annual incidence rate 1/lac. There are no specific biomarkers, diagnostic and prognostic tests available for PanNET. The small extracellular vesicles (sEV) play a key role in tumour growth and metastasis and can be a potential biomarker for metastasis of PanNET.

Conference:

Presenting Author:

Authors: As S, Gorai P, Naik M, Kumar R, Kumar S,

Keywords: Metastasis, Pancreatic neuroendocrine tumour, Small extracellular vesicles, Fluorescence, Nanoparticle tracking analysis,

#4119 Interim analysis of LANTana: Phase Ib study investigating up-regulation of somatostatin receptor-2 (SSTR2) with the de-methylating agent ASTX727 to allow [177Lu]Lu-DOTA-TATE in metastatic neuroendocrine tumors (NETs)

Introduction: To be suitable for [177Lu]Lu-DOTA-TATE, SSTR2 must be present on tumor surface as per positive uptake on [68Ga]Ga-DOTA-TATE-PET/CT. SSTR2 promoter methylation reduces SSTR2 expression; this can be reversed using a demethylating agent.

Conference:

Presenting Author:

Authors: Rzeniewicz K, Ward C, Khan S, Naik M, Qurashi M,

Keywords: neuroendocrine tumor, peptide receptor radionucleotide therapy, methylation, [68Ga]Ga-DOTA-peptide-PET, [177Lu]Lu-DOTA-TATE,

#2118 Reassessment of Risk Factors Associated with Locoregional Lymph Nodal Metastases in Well-Differentiated Appendiceal Neuroendocrine Neoplasms

Introduction: To prevent loco-regional recurrence and subsequent development of distant metastases in Appendiceal Neuro-Endocrine Neoplasms (ANEN), the existing Guidelines have identified risk factors which would indicate a prophylactic right hemicolectomy(RHC).

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Galanopoulos M, Evans N, McFadyen R, Naik R, Drami I,

Keywords: appendix, neuroendocrine neoplasm, lymph node metastases, appendicectomy, right hemicolectomy,

#1072 Predictive Factors for Antiproliferative Activity of Octreotide LAR in Advanced Neuroendocrine Tumors

Introduction: The antiproliferative activity of Octreotide LAR in Neuroendocrine Tumors(NETs) has been demonstrated by small retrospective studies and confirmed by a prospective phase III trial(PROMID).However,there are limited data about the duration and predictors of response.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Toumpanakis C

Authors: Toumpanakis C, Laskaratos F, Maragkoudakis E, Naik K, Oikonomopoulos N,

Keywords: octreotide LAR, NETs,