Abstract Library

#4515 Prognostic factors for survival in patients with metastatic small intestinal neuroendocrine tumours undergoing primary tumour resection

Introduction: Although guidelines recommend primary tumour resection in metastatic small intestinal neuroendocrine tumours (SI-NETs) to manage symptoms and complications, the survival benefit and optimal surgical approach remain unclear.

Conference:

Presenting Author:

Authors: Dell' Unto E, Ogunbiyi O, Mirnezami R, Malam Y, Yasin Y,

Keywords: Small Intestinal Neuroendocrine Tumour, surgery, midgut carcinoid,

#4462 Clustering of gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) using machine learning (ML) and comparison with tumour, node, metastasis (TNM) staging: A population-based study using surveillance, epidemiology, and end results (SEER)

Introduction: TNM 8 is the staging system for GEP-NEN, guiding prognosis and treatment. However, it does not include important prognostic factors such as age, sex, race, and morphology.

Conference:

Presenting Author: Mortagy M

Authors: Mortagy M, El Asmar M, White B, Chandrakumaran K, Ramage J,

Keywords: Clustering, Machine learning, GEP-NEN, TNM Staging, Survival Analysis, SEER,

#4461 Systemic anti-cancer therapy in gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC): Insights from National Cancer Registration and Analysis Service (NCRAS)

Introduction: ENETS advocates the use of platinum-based chemotherapy in combination with Etoposide as first-line chemotherapy in advanced GEP-NEC. Available retrospective evidence is from small studies.

Conference:

Presenting Author: Mortagy M

Authors: Mortagy M, El Asmar M, Paisey S, White B, Chandrakumaran K,

Keywords: Systemic anti-cancer therapy, Chemotherapy, GEP-NEC, NCRAS,

#4439 Survival of 10,418 lung neuroendocrine tumours after surgical resection: Who needs follow-up and for how long?

Introduction: Surgical resection is the primary treatment for lung neuroendocrine tumours (NETs). The optimal follow-up period is debated in these patients.

Conference:

Presenting Author: El Asmar M

Authors: El Asmar M, Mortagy M, Chandrakumaran K, Ramage J,

Keywords: Lung, Neuroendocrine tumour, survival, surgery, follow-up period,

#4423 Exploring decorin in plasma-derived small extracellular vesicles (sEVs) as a potential diagnostic biomarker for pancreatic neuroendocrine tumours

Introduction: Pancreatic Neuroendocrine tumours (PanNETs), the most common site for GEP‑NENs in Asian countries, particularly India, have shown increasing incidence. Due to a lack of specific biomarkers, often detected at advanced stages. So, this study utilised PanNET tissue proteomics for cancer biomarker discovery and explored the impact of small extracellular cellular vesicles (sEVs) in PanNET growth and metastasis, as they reflect the molecular profile of their tissue of origin.

Conference:

Presenting Author:

Authors: Gorai P, As S, Naik M, Kumar S, Pal S,

Keywords: Decorin, small extracellular vesicles, Pancreatic Neuroendocrine Tumour, Proteomics, circulating biomarker,