#2982
Comprehensive Molecular Analysis Identifies Driver Mutations in Metastases of Sporadic Well-Differentiated Neuroendocrine Tumours of the Small Intestine
Introduction:
Small intestinal neuroendocrine tumours (SI-NETs) represent a heterogenous group of tumours. The molecular mechanisms which contribute to progression of SI-NETs are poorly elucidated. They are considered to be molecularly distinct from neuroendocrine carcinomas (NECs), which share oncogenic pathways with adenocarcinomas.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Samsom K
Authors:
Samsom K,
van Veenendaal L,
Roepman P,
Kodach L,
Steeghs N,
Keywords:
whole genome sequencing,
neuroendocrine tumour,
small intestine,
genetics,
#2980
Metabolic Dysregulation and Circadian Clock in Cellular Models of Neuroendocrine Tumors
Introduction:
The circadian clock genes encode transcription factors whose interaction with nuclear receptors allows the regulation of cellular metabolism.The invalidation of the genes of the clock core is associated with the development of many endocrine diseases including neuroendocrine cancer. Recently, the family of transcriptional coactivators PGC-1a has been identified as a key element in the integration of cellular metabolic state with the circadian clock. PRC, as a member of the PGC-1 family, was able to interact with several transcription factors, including the CLOCK factor. The specific induction of this PRC factor by the cell cycle, to modulate the energy function, the MAPkinase pathway and the expression of microRNAs, makes it a key factor in the metabolic adaptation of cancer cells.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Savagner F
Authors:
Savagner F,
Le Pennec S,
Keywords:
Metabolism,
Circadian clock,
cell models,
#2975
Next Generation Sequencing of Pancreatic Neuroendocrine Tumors in Russian Cohort
Introduction:
The appearance of next generation sequencing (NGS), - a powerful high-performance method, allowed accumulation of a large amount of information concerning genetic and epigenetic patterns, however, the problem of matching clinical, histological picture with genetic structure in pNETs remains open.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Trifanov V
Authors:
Trifanov V,
Kit O,
Timoshkina N,
Gvaldin D,
Karnauhov N,
Keywords:
Next generation sequencing,
pancreatic neuroendocrine tumors,
