Abstract Library
Welcome to the open-access search for all ENETS abstracts presented at the Annual ENETS Conferences.
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Introduction: Neuroendocrine neoplasms (NENs) consist of neuroendocrine tumours and neuroendocrine carcinomas, which are rare malignancies found in various anatomical sites, including the gastrointestinal tract, pancreatic islets, lungs, and adrenal glands. Poorly differentiated NECs are classified as high-grade carcinomas that bear resemblance to small-cell lung cancer; however, these patients experience a high risk of relapse and demonstrate a limited response to additional systemic therapies. Adrenocortical carcinoma (ACC) is another rare cancer and currently, no targeted therapies have demonstrated significant effectiveness for this condition. Preclinical investigations have indicated that Delta-like non-canonical notch ligand 1 (DLK1) is expressed in various neuroendocrine neoplasms, including ACC, SCLC, neuroblastoma, pheochromocytoma, and paraganglioma.
Conference:
Presenting Author: Del Rivero J
Authors: Del Rivero J, Glod J, Magee T, Cooper K, Rivero A,
Introduction: DCC functions as a tumor suppressor and is altered in various tumors, including neuroendocrine neoplasms. Netrin (NTN)-1 serves as the primary ligand for DCC. Operating as a dependence receptor, DCC induces apoptosis without NTN and promotes cell survival in its presence. In some cancers like small cell lung cancer and neuroblastoma, upregulation of NTN-3 rather than NTN-1 has been observed. However, the precise involvement of NTNs and DCC in PNEN remains unclear.
Conference:
Presenting Author: Sela Peremen L
Authors: Sela Peremen L, Telerman A, Peshes Yaloz N, Tirosh A,
Keywords: neuroendocrine, netrin, pancreatic neuroendocrine tumor, dcc,
#3859 Molecular landscape of splicing dysregulation in pheochromocytomas and paragangliomas
Introduction: Pheochromocytomas and paragangliomas (PPGL) are commonly benign neuroendocrine tumors (NETs). However, up to 25 % of patients develop metastases or aggressive behaviour. Genomic characterization current classifies PPGL into different genetic clusters, yet there are no biomarkers which could stratify patients based on their prognosis. The dysregulation of the splicing process has emerged as a novel feature, common in most cancers, and linked to a more aggressive phenotype in several tumors, including NETs, but this process has not been examined in detail in PPGL.
Conference:
Presenting Author:
Authors: Moreno Montilla M, Blázquez-Encinas R, Martínez Montes �, García Vioque V, Alors-Pérez E,
Keywords: pheochromocytoma, paraganglioma, splicing dysregulation, splicing machinery, pladienolide B,
Introduction: Intra-abdominal Neuroendocrine Tumors (NETs) usually metastasize to regional lymph nodes, liver, and bone. Myelophthisis (MPT) is the destruction of the medullary microenvironment due to the tumoral invasion of the trabecular space, altering normal hematopoiesis; it’s frequently caused by metastasis of breast, prostate, and lung adenocarcinomas, and neuroblastoma. MPT due to NET is an unrecognized phenomenon with few cases reported, almost exclusively in poorly differentiated NETs.
Conference:
Presenting Author:
Authors: González Devia D, Aldana-Gómez L, Segovia Gómez J, Ortiz-Santacruz C, Mejía-Arango M,
Keywords: Neuroendocrine Tumor, Myelophthisis, Colon tumor, Prostate tumor, End-stage,
#3423 MIBG scintigraphy in metastatic neuroblastoma: A retrospective study of 25 cases
Introduction: Meta-iodobenzylguanidine (MIBG) scintigraphy is the first-line functional imaging agent used in neuroblastoma imaging, identifying both the primary tumor and sites of metastatic disease.
Conference:
Presenting Author:
Authors: Ghomari C, Nasri A, Tahraoui Z, Merad S, Medjahedi A,
Keywords: I-MIBG, neuroblastoma, metastasis,