#1559
MTOR Controls an Epigenetic Program Leading to Autophagy and Cell Growth Control
Introduction:
Makroautophagy represents an evolutionary highly conserved process involved in the clearance of proteins and organelles. The induction of this central cellular process is tightly connected with programs regulating cell growth control. While the cytoplasmic machinery that orchestrates autophagy is relatively well understood the key epigenetic events that initiate autophagy-related cell growth programs remain largely unknown.
Conference:
13th Annual ENETSConcerence (2016)
Presenting Author:
Koenig A
Authors:
Koenig A,
Hessmann E,
Hanheide S,
Gaedcke J,
Zhang J,
Keywords:
autophagy,
G9a,
p27Kip1,
mTOR,
epigenetic growth control,
#1494
CDK-Inhibitors as New Therapeutic Treatment for Human Bronchial Carcinoids
Introduction:
Bronchial Carcinoids (BC) are still orphan of medical therapy. We previously demonstrated that 70% of primary BC cultures are sensitive to Everolimus (E), an mTOR inhibitor, while 30% are not. We also observed that in 2 human BC cell lines, the NCI-H720 (sensitive to E) and NCI-H727 (resistant to E), mTOR resistance may be linked to a differential cell cycle protein expression (CyclinD1/E, CDK2/4, p27kip1/p27kip1phospho-Ser10), which is higher in BC resistant to E as compared to sensitive ones, suggesting an impaired p27 function
Conference:
13th Annual ENETSConcerence (2016)
Presenting Author:
BENFINI K
Authors:
Benfini K,
Gentilin E,
Riva E,
Di Pasquale C,
Falletta S,
Keywords:
Bronchial Carcinoid,
Medical Therapy,
mTOR Resistance,
CDK inhibitors,
#1090
p27kip1 Is Involved in the Resistance of Human Bronchial Carcinoids to m-TOR Inhibitors
Introduction:
Bronchial carcinoids (BC) are still orphan of medical therapy. We previously demonstrated that the typical BC human cell line NCI-H727 is sensitive to Everolimus (E), in terms of cell viability reduction, with a G0 cell-cycle arrest, while the atypical human BC cell line NCI-H720 is not. The mechanisms underlying this phenomenon have not been clarified
Conference:
12th Annual ENETSConcerence (2015)
Presenting Author:
Authors:
Benfini K,
Gagliano T,
Gentilin E,
Falletta S,
Di Pasquale C,
Keywords:
RAD001,
BC,
p27kip1,Cell cycle,
#962
Cyclin D1 Levels are Involved in the Resistance to m-TOR Inhibitors in Human Bronchial Carcinoids
Introduction:
Bronchial carcinoids (BC) are still orphans of medical therapy. We previously demonstrated that the typical BC human cell line NCI-H727 is sensitive to Everolimus, in terms of cell viability reduction, while the atypical human BC cell line NCI-H720 is not. However, the mechanisms underlying this phenomenon have not been fully clarified.
Conference:
11th Annual ENETSConcerence (2014)
Presenting Author:
Authors:
Benfini K,
Gagliano T,
Gentilin E,
Minoia M,
Molè D,
Keywords:
BC,
mTOR,
