#4163
Metabolite biomarker discovery for pancreatic neuroendocrine tumors using metabolomic approach
Introduction:
Metabolic flexibility is one of the key hallmarks of cancer and metabolites are the final products of this adaptation, reflecting the tumors’ aberrant changes. However, the metabolic plasticity of pancreatic neuroendocrine tumors (pNET) is still unknown. pNETs are heterogeneous which makes their diagnosis, prognosis and therapeutic management difficult.
Conference:
Presenting Author:
Authors:
Jannin A,
Dessein A,
Dabo S,
Descat A,
Vantyghem M,
Keywords:
pancreatic NET,
diagnostic biomarker,
plasma metabolites,
molecular pathways,
#3446
Metabolomic profile of extra-pancreatic NET: A novel prognostic tool?
Introduction:
Reprogrammed metabolism is one of the key hallmarks of cancer. Thus, metabolic profiling of cancer patients represents a promising tool. To date, metabolomics remains largely unexplored in NETs.
Conference:
Presenting Author:
Authors:
La Salvia A,
Soldevilla B,
Lens-Pardo A,
López-López A,
Carretero C,
Keywords:
NET,
metabolic signaling,
molecular pathways,
plasma metabolites,
prognostic biomarker,
#3271
Comprehensive metabolomic plasma profiling identifies novel potential diagnostic biomarkers in patients with advanced neuroendocrine tumors
Introduction:
NETs are heterogeneous neoplasms that have the capacity to secrete hormones or bioactive molecules. Dysregulated metabolism is one of the key hallmarks of cancer and the altered expression of metabolic enzymes is deeply involved in tumor development, progression, and metastasis.
Conference:
18th Annual ENETS Concerence (2021)
Presenting Author:
Authors:
Soldevilla B,
Lens-Pardo A,
López-López �,
Carretero-Puche C,
La Salvia A,
Keywords:
NETs,
metabolic signalling,
plasma metabolites,
diagnostic biomarker,
