Abstract Library

#4151 Identifying potential tumor drivers through integration of gene expression and DNA copy number in SI-NET

Introduction: The genetics of small intestine neuroendocrine tumors (SI-NETs) remains poorly understood. To date, only CDKN1B has been found recurrently mutated, in approximately 9% of cases. On the contrary, DNA copy number alterations are found in a majority of cases. The most frequent aberration is heterozygous loss of chromosome 18. In addition, loss of chromosome 11, and gains on chromosomes 4, 5 and 14 are common. The cellular mechanisms through which these alterations drive tumor development are unknown.

Conference:

Presenting Author: Backman S

Authors: Backman S, Barazeghi E, Norlén O, Hellman P, Stålberg P,

Keywords: SI-NET, RNA-Seq, Gene dosage, Haplo-insufficiency, Copy number,

#4041 Mesenteric fibrosis in small intestinal neuroendocrine tumors (SI-NETs): Pathogenesis and therapeutic targets

Introduction: Mesenteric fibrosis (MF) affects up to 50% of small intestine neuroendocrine tumor (SI-NET) patients, causing significant morbidity and mortality. MF pathophysiology is poorly understood, limiting treatment development and biomarker identification.

Conference:

Presenting Author:

Authors: Castanho Martins M, Hodgetts H, Lemos Dias M, Luong T, Hall A,

Keywords: fibrosis, small intestine, 3D model, cell crosstalk, microenvironment, cancer-associated fibroblast,

#3749 Elevated inflammatory markers are associated with poor survival after surgery for pancreatic and small intestine neuroendocrine tumors

Introduction: Gastroenteropancreatic neuroendocrine tumors (GEP-NET) are a heterogenous group of neoplasms. The only curative treatment is surgery. However, predictors of survival after surgery are still missing.

Conference:

Presenting Author:

Authors: Amin T, Kailani S, Fründt T, Viol F, Stripling J,

Keywords: Neuroendocrine tumor, inflammatory marker, GEP-NET, overall survival,

#3639 Tumor uptake on 18FDOPA PET/CT is a strong prognostic factor in patients with metastatic small intestine neuroendocrine tumors (siNETs) – A GTE study

Introduction: 18FDOPA PET/CT has high diagnostic performances for siNETs. Its prognostic role is unknown.

Conference:

Presenting Author: de Mestier L

Authors: de Rycke O, Imperiale A, Perrier M, Bando-Delaunay A, Mennetrey C,

Keywords: FDOPA PET/CT, prognosis, small intestine NETs,

#3329 The role of 68Ga-DOTATATE PET/CT in extensive IgG4-positive fibrosis surrounding a mesenteric lymph node metastasis of a neuroendocrine tumor: A case report

Introduction: IgG4 expression is commonly seen in mesenteric tumor deposits from small intestine neuroendocrine tumors leading to a dense fibrotic response which can simulate IgG4-related sclerosing mesenteritis in medical images, hereby impeding a correct diagnosis.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Ahmadi Bidakhvidi N, Cuyle P, Sagaert X, Ballaux F, De Bruecker Y,

Keywords: small intestine neuroendocrine tumor, 68Ga-DOTATATE PET/CT, mesenterial lymph node, fibrosis, IgG4,