Abstract Library

#2693 The Distinctive Character of Micro-Vasculature and Immune Cell Infiltration in Cystic Pancreatic Neuroendocrine Tumors

Introduction: Hypervascularity is main character of pancreatic neuroendocrine tumors (PanNETs), cystic PanNET (CPanNET) are unique type of PanNETs for which the microenvironment remains unknown.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Gao H,

Keywords: pancreatic neuroendocrine tumors, cystic, microvascular density, microvascular integrity, tumor-associated macrophage,

#2684 Tumour-Infiltrating Neutrophils Predict Poor Survival of Non-Functional Pancreatic Neuroendocrine Tumour Patients after Curative Resection

Introduction: Non-functional pancreatic neuroendocrine tumours (NF-PanNETs) are steadily increasing in prevalence and present several clinical challenges.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Zhang W, Wang W,

Keywords: non-functional pancreatic neuroendocrine tumours, tumour immune microenvironment, tumour-infiltrating neutrophils, prognosis, predictors,

#2199 Systematic Evaluation of the Immune Microenvironment of Neuroendocrine Tumors (NET)

Introduction: Immunotherapy is being explored in many tumour types with encouraging results, but its role in the management of NET is yet to be defined.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Vesely C

Authors: Vesely C, Childs A, Wong Y, Ogunbiyi O, Gander A,

Keywords: immunotherapy, neuroendocrine tumor, immune landscape, checkpoint molecules, t cells,

#2148 Tumor Microenvironment in Merkel Cell Carcinoma: Association with Merkel Cell Polyomavirus and Clinico-Pathological Features in a Retrospective Cohort Study

Introduction: MCC is a rare and aggressive skin cancer with a neuroendocrine phenotype.Association between MCC and Polyomavirus is known.PD-1 and PD-L1 have recently become key players in the therapeutic landscape.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Birocco N

Authors: Mecca C, Maletta F, Caliendo V, Birocco N, Metovic J,

Keywords: merkel cell carcinoma, microenvironment, polyomavirus,

#1945 Metabolic Adaptation to Anti-Angiogenic Therapy

Introduction: Although anti-angiogenic inhibition (AI) therapy has demonstrable efficacy in mouse models of cancer and in certain types of human cancer, responses are typically transitory, followed by resumption of malignant progression that limits survival benefit. Unconventional modes of evasive/adaptive resistance underlay the eventual failures of anti-angiogenic therapy. Functionally established resistance mechanisms include revascularization mediated by alternative pro-angiogenic signals, protection by peri-vascular macrophages and monocytes to induce an immunosuppressive microenvironment, and normal vessel cooption via heightened local invasion and distant metastasis. All three mechanisms have been documented in the prototypical RIP-Tag2 mouse model of multistep tumorigenesis, in which the angiogenic switch is a discrete step in the pathway to invasive pancreatic neuroendocrine cancer.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Allen E

Authors: Allen E,

Keywords: AI/mTOR,