Abstract Library

#3757 Subtype-specific landscape of splicing-associated neoantigens and mutations in pancreatic neuroendocrine tumors

Introduction: In pancreatic neuroendocrine tumors (PanNETs), there has recently been advancement in understanding the heterogeneity (metastases-like primary; MLP-1/2, intermediate, and insulinoma subtypes) and immunological landscapes. Immunotherapies provide modest therapeutic benefits to patients, which may be linked to low mutational neoantigen loads in PanNETs.

Conference:

Presenting Author: Sadanandam A

Authors: Sadanandam A, Lawlor R, Larkeryd A, Mahalingam A, Mafficini A,

Keywords: Pancreatic neuroendocrine tumor, isoform switching, subtype, mutation, neoantigens, splice variant, spliceosomal mutation, immunotherapy, immunosuppression,

#930 Distinct Expression of Splicing Variants of the Human MEN1 (Multiple Endocrine Neoplasia Type 1) Gene in Various Pituitary Adenomas

Introduction: MEN1 is an autosomal-dominant tumor syndrome characterized by the occurrence of tumors in multiple endocrine tissues, including parathyroid, enteropancreatic neuroendocrine and anterior pituitary. The MEN1 gene consists of 10 exons transcribed into a 610 a.a. protein. It was reported that heterogeneity of human MEN1 gene transcripts related to variation in their 5’ UTR. Six distinct exsons1 (e1A-e1F) were isolated using RNA from thymus, pancreas and kidney.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Ozawa A

Authors: Ozawa A, Watanabe T, Tosaka M, Yoshimoto Y, Horiguchi K,

Keywords: MEN1, pituitary,

#529 Alternative Splicing and Differential Gene Expression in Pancreatic NETs

Introduction: Protein isoforms resulting from differentially spliced mRNA may constitute peculiar drug targets or markers for cancer diagnosis. We here present a new DNA array that allows identification of splice variation and differential expression for 357 G protein-coupled receptors (GPCR) and 11 proteins of the extracellular matrix.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Körner J, Schäfer C, Schulz P, Wiedenmann B, Grötzinger C,

Keywords: pNET,

#357 Alternative Splicing and Differential Gene Expression in Pancreatic NETs

Introduction: Alternative splicing is an important mechanism to increase diversity of the proteome in higher organisms. These protein isoforms can provide as a selective drug target or marker for cancer diagnosis. We present here a new DNA array that allows identification of splice variation and differential expression of 357 G protein-coupled receptors (GPCR) and 11 proteins of the extracellular matrix.

Conference:

Presenting Author:

Authors: Körner J, Wiedenmann B, Grötzinger C,

Keywords: splice variants array,