Abstract Library

Welcome to the open-access search for all ENETS abstracts presented at the Annual ENETS Conferences.

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#3323 Anti-immune defences involving down-regulation of MHC-I or beta-catenin activation do not explain immune coldness of pancreatic or ileal neuroendocrine tumors

Introduction: Our previous study demonstrated pancreatic (PNET) and ileal neuroendocrine tumors (INETs) are immunologically cold, containing very few tumor infiltrating lymphocytes (TILs) compared to non-small cell lung cancers. This raises the questions of whether there is in fact, a weak anti-tumor immune response taking place or whether the tumors are deploying effective anti-immune defences such as down-regulation of MHC class I or activation of β-catenin signalling.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Tanno L

Authors: Tanno L, Naheed S, Lopez M, Taylor J, Machado M,

Keywords: pancreatic neuroendocrine tumor, ileal neuroendocrine tumor, beta-catenin pathway, tumor immune microenvironment, major histocompatibility complex 1,

#3322 Analysis of immune landscape in pancreatic and ileal neuroendocrine tumors demonstrates an immune cold tumor microenvironment

Introduction: Neuroendocrine tumors (NETs) are rare tumors with an increasing incidence. While low and intermediate-grade pancreatic (PNET) and ileal (INET) tumors are slow-growing, they have a relatively high rate of metastasis to the liver where the outcome is much worse. For most cancers, the outcome is determined by the quality of the anti-tumor immune response. However, the quality and significance of anti-tumor responses in NETs are incompletely understood.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Tanno L, Naheed S, Dunbar J, Tod J, Lopez M,

Keywords: pancreatic neuroendocrine tumor, ileal neuroendocrine tumor, tumor immune microenvironment, tumor infiltrating lymphocytes,

#3097 Infiltrating pattern and prognostic value of tertiary lymphoid structures in pancreatic neuroendocrine tumors

Introduction: Tertiary lymphoid structures (TLS) are associated with favourable survival and play a critical role in most solid tumors. However, investigations of TLS are lacking in grade 1 or grade 2 (G1/G2) non-functional pancreatic neuroendocrine tumor (NF-PanNET) patients.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Zhang W

Authors: Zhang W, Wang W, Han X, Gao H, Yu X,

Keywords: non-functional pancreatic neuroendocrine tumors, tertiary lymphoid structures, tumor immune microenvironment, prognosis, nomogram,