A Head-to-Head Comparison between Two Software Packages for Hybrid Dosimetry after PRRT


Introduction: The number of dosimetry studies after PRRT is increasing, yet different methodologies are used which challenge comparison or pooling of results.

Aim(s): To perform a head-to-head comparison of post-PRRT dosimetry results from different methodologies using two commercial software packages.

Materials and methods: Hybrid Viewer Dosimetry module together with OLINDA/EXM v2.1 (Hermes Medical Solutions) and PLANET Dose (DOSIsoft) were used to perform dosimetry after the first PRRT cycle using four imaging time points. Multiple fitting methods for the time-activity curve were assessed and goodness of fit was evaluated using Spearman’s rank correlation. The intraclass correlation coefficient (ICC) and bias calculated using Bland-Altman analysis were used to compare the dosimetric outcome of the software packages.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Huizing D, Peters S, Versleijen M, Martens E, Verheij M,

Keywords: dosimetry, PRRT, quantification,

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