An Isolated Abnormal Chromogranin B Is Associated with Pancreato-Duodenal NETs and the Presence of Liver Metastases


Introduction: Chromogranin B (CgB) is a soluble secretory protein like chromogranin A (CgA) that has been reported to be elevated in patients with neuroendocrine tumours (NETs) but is not routinely assessed.

Aim(s): This study explores whether an abnormal CgB paired with a normal CgA provides any useful clinical information in NET patients.

Materials and methods: A prospective NET database (01/2007-11/2014) was interrogated for paired radioimmunoassay CgA (two assays; normal <6 nmol/L & 60 pmol/L) and CgB (two assays, normal <3 nmol/L, <150 pmol/L) results.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Basuroy R, Sherwood R, Srirajaskanthan R, Ramage J,

Keywords: chromogranin A, chromogranin B, pancreas, duodenal, assay, liver metastases,

To read the full abstract, please log into your ENETS Member account.