Circulating Gene Transcript Analysis of Pancreatic NETs


Introduction: PNETs are aggressive with poor survival. Therapeutic agents are available but efficacy determination is limited by imaging insensitivity and the lack of effective blood biomarkers.

Aim(s): Examine the utility of a blood transcript signature in comparison to CgA measurement.

Materials and methods: We assessed 2 separate prospectively collected datasets. Set 1: Graded PNETs (n=65; 25 resections). Set 2: unknown pancreas disease (n=61: pancreatitis n=4, cyst n=31, NET n=4, adenoCa n=22). Set 1 and 2: Gene expression (qPCR) and CgA (DAKO) were compared (χ2, non-parametric). Metrics were calculated for the entire cohort (n=126). Status was assessed clinically + RECIST. NETest index defined disease activity scaled 0-100%; minimal <20%, low 20-47%, high >47%.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Kidd M

Authors: Kidd M, Modlin I, Drozdov I, Alaimo D, Callahan S,

Keywords: PNET, NETest, PCR,

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