Comprehensive transcriptomic and methylomic analysis of NENs from multiple origins show subgroups of patients with clinical relevance

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Introduction: Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors with a wide anatomical distribution that share common neuro and endocrine properties. Although some studies have assessed the NET molecular landscape of certain primary sites, none of them have evaluated cross-sites molecular studies.

Aim(s): We aimed to perform transcriptomic and methylomic characterization of a large serie of NENs with different origins in order to identify molecular subgroups, unravel genes and/or pathways involved, and explore their potential clinical relevance.

Materials and methods: Transcriptomic and methylation data were obtained from 181 and 99 NEN tumor samples from different primary sites. Clustering was performed independently in each database and differential expression a and gene set GSEA was applied among the resulting clusters.

Conference:

Presenting Author: Carretero C

Authors: Carretero C, Soldevilla B, Gil B, La Salvia A, Lens-Pardo A,

Keywords: neuroendocrine tumor, multiomics, subtypes,