Detection of cardiac metastases in patients with neuroendocrine tumors: comparison of Ga-68 DOTA-SMS-R PET/CT, cardiac MRI, CT scan and 2D echocardiography

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Introduction: Neuroendocrine tumor metastases to the heart have been sparsely reported in literature. There is as of yet no detailed study on the best imaging method for the detection of this rare site of metastases.

Aim(s): To investigate the diagnostic accuracy of molecular, morphological and functional imaging modalities for the detection of heart metastases (HM) in neuroendocrine tumor (NET) patients.

Materials and methods: Overall, 713 progressive NET patients were examined with Ga-68 DOTA-Somatostatin-Receptor (SMS-R) PET/CT (using mainly DOTA-NOC and DOTA-TATE) and 2D echocardiography (echo). Twenty-eight patients had HM (incidence 4%). In 12 patients, cardiac MRI was also performed; FDG PET/CT was available in 24 patients. All imaging studies were reviewed separately by two independent experts. Cases were classified based on confirmation of HM in functional and morphological studies. The diagnostic accuracy of SMS-R-PET/CT, cardiac MRI, echo and thoracic CT scan studies was compared.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Prasad V, Ali S, Secknus M, Lauer B, Hoersch D,

Keywords: neuroendocrine tumors, cardiac metastases, Ga-68 SMS-R PET/CT, echocardiography, MRI,

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