Abstract Library

#2971 A Retrospective Multicentre Evaluation of the Outcomes and Management of Carcinoid Heart Disease in Patients with Advanced Midgut NETs: A NET-CONNECT Descriptive Study

Introduction: Carcinoid heart disease (CHD) is a poor prognostic factor in neuroendocrine tumours (NETs). However, the extreme variability of diagnostic and treatment approaches reported in literature account for uncertainties on the best management in this selected population.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Spada F

Authors: Spada F, Laskaratos F, Crona J, Oleinikov K, Zandee W,

Keywords: Carcinoid Heart Disease, NETs, Carcinoid Syndrome, Midgut NETs,

#2944 Soluble ST2 (sST2) Levels in the Management of Carcinoid Heart Disease in Patients with Neuroendocrine Cancer

Introduction: The identification of a sensitive biomarker to detect the presence and severity of carcinoid heart disease could allow more selective use of clinical and echocardiographic screening. ST2 is a protein belonging to the family of interleukin 1 receptors, present both in the isoform of transmembrane (ST2L) and in the soluble one (sST2). sST2 blocks the anti-inflammatory, anti-hypertrophic, and anti-fibrotic effects of cytokine IL-33 on the myocardium and recent studies have shown that sST2 levels increase in the blood of patients diagnosed with heart failure.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Salvatici M, Zorzino L, Fabiani I, Cardinale D, Fazio N,

Keywords: sST2, Biomarkers, Carcinoid Heart Disease,

#2260 Carcinoid Heart Failure in a Metastatic Duodenal Neuroendocrine Tumor: A Challenging Case Report.

Introduction: Carcinoid heart disease (CHD) is a potenzial fatal cardiac manifestation, characterized by fibrous endocardial thickening involving right-sided heart valves. In 70% of cases, CHD occurs in advanced small bowel NETs with carcinoid syndrome (CS). Serotonin seems to play a main role. Early recognition and surgical intervention may improve the outcome of patients.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Brizzi M

Authors: Brizzi M, La Salvia A, Parisi F, Scagliotti G,

Keywords: Carcinoid Hearth Disease, Carcinoid syndrome, Surgery, somatostatin analogues,

#1997 Carcinoid Heart Disease - Diagnostic Usefulness of Cardiac Computed Tomography – A Pilot Study

Introduction: Carcinoid heart disease (CHD) is a rare entity which occurs from 20 to 40% patients with carcinoid syndrome.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Michałowska I, Kolasińska-Ćwikła A, Ćwikła J, Konka M, Kwiatek P,

Keywords: carcinoid heart disease, computed tomography,

#1762 Prevalence of Carcinoid Heart Disease in Patients with Disseminated Small Intestinal NET

Introduction: In patients with small intestinal neuroendocrine tumours (SI-NETs), serotonin may induce fibrosis and lead to carcinoid heart disease (CHD) with right sided valvular dysfunction.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Groenbaek H

Authors: Dam G, Rasmussen V, Oksjoki R, Villadsen G, Grønbæk H,

Keywords: carcinoid heart disease, SI-NET,