Hyperinsulinemic Hypoglycemia by an Ovarian Germ Cell Tumor

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Introduction: A 76-yr-old woman was admitted to our department for recurrent hot flushes, sweating and dizziness associated with fasting hypoglycemia. Physical examination revealed abdominal obesity and ascites.

Aim(s):

Materials and methods: Fasting test was performed and at the fifth hour, the patient showed neuroglycopenia symptoms and blood samples revealed inappropriately elevated insulin and C-peptide levels. An abdominal US showed a 10 cm diameter disomogeneous mass in the left adnexal region, CT confirmed the necrotic-colliquative expansive lesion in left adnexal and described ascites. Blood tests showed abnormal levels of CgA, CEA, AFP, CA125, CA19.9, LH, FSH, testosteron, progesteron and 17-β-estradiol; normal values of βHCG, NSE and CA15.3. A 18FDG-PET described pathological uptake in left adnexal while Octreoscan® was negative.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Battocchio M, Martini C, De Carlo E, Zatelli M, Trento M,

Keywords: ovary, insulin, SSA, everolimus,