Longitudinal changes in Ki-67 index in a prospective cohort of pancreatic neuroendocrine tumors

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Introduction: The biology of pancreatic neuroendocrine tumors (panNET) can change over time. In retrospective cohorts, many panNETs showed longitudinal increases in Ki-67 index leading to a higher tumor grade and poor survival. However, data from prospective studies are lacking, and non-invasive methods of determining tumor grade progression are needed in order to monitor and guide further treatment.

Aim(s): We aimed to study longitudinal changes in panNET tumor biology and to correlate changes in Ki-67 index with clinical parameters and PET imaging.

Materials and methods: This was a single-center, prospective cohort study at Uppsala University Hospital (NCT03130205) including previously diagnosed metastatic panNET patients at the event of progressive disease. Dual FDG- and SSTR-PET as well as core-needle biopsy were performed at inclusion, and at further progression accordingly to clinical criteria.

Conference:

Presenting Author: Mollazadegan K

Authors: Mollazadegan K, Botling J, Welin S, Zhang L, Eriksson B,

Keywords: neuroendocrine tumor, pancreas, high-grade, poor prognosis, biomarker, Ki-67,