Metastatic middle ear neuroendocrine tumor treated with Somatostatin analogues and PRRT – A case report

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Introduction: Neuroendocrine adenomas of the middle ear (NEAME) are rare tumors. They have mostly indolent biological behaviour, however, reports of an aggressive course and metastasis have been described.

Aim(s): To describe a case of NEAME treated with somatostatin analogues (SSA) and peptide receptor radionuclide therapy (PRRT).

Materials and methods: 72-year-old man with past history of a middle ear tumor submitted to surgery. After 6 years, recurrence of the disease was detected and he underwent right subtotal petrosectomy, total parotidectomy and radical neck and parapharyngeal lymph node dissection. Histology revealed a middle ear neuroendocrine tumor with metastatic cervical lymph nodes (Ki-67 SI:6%). Macroscopic positive margins were observed. Ga-68-DOTA-NOC PET/CT scan performed later exhibited high uptake in the temporal bone, latero-cervical region, retropharyngeal soft tissues and C1 vertebra suggesting metastasis.

Conference:

Presenting Author: Gomes Martins R

Authors: Elvas A, Magalhães J, Monteiro J, Barros J, Rei L,

Keywords: Neuroendocrine adenomas of the middle ear, somatostatin analogues, peptide receptor radionuclide therapy,