Abstract Library

#4305 Lower dose of lenvatinib is similarly effective as higher dose for patients (pts) with advanced neuroendocrine tumours (NETs): A multinational retrospective cohort

Introduction: A phase II trial with lenvatinib 24mg PO daily was effective for pts with gastroenteropancreatic (GEP) NETs but led to significant toxicity. In clinical practice, dose reductions are commonly required.

Conference:

Presenting Author: Riechelmann R

Authors: Zanetta G, Grozinsky-Glasberg S, Bel-Ange A, Barros M, Felismino T,

Keywords: lenvatinib, neuroendocrine tumour, dose optimisation, toxicity,

#3570 Metastatic middle ear neuroendocrine tumor treated with Somatostatin analogues and PRRT – A case report

Introduction: Neuroendocrine adenomas of the middle ear (NEAME) are rare tumors. They have mostly indolent biological behaviour, however, reports of an aggressive course and metastasis have been described.

Conference:

Presenting Author: Gomes Martins R

Authors: Elvas A, Magalhães J, Monteiro J, Barros J, Rei L,

Keywords: Neuroendocrine adenomas of the middle ear, somatostatin analogues, peptide receptor radionuclide therapy,

#3250 High TMB and MSI-high as independent predictors of survival in NENs

Introduction: To date, there are no validated molecular biomarkers for personalized therapy in NENs. Tumor genome sequencing may help unravel NEN molecular landscape and identify novel targets for an individualized approach.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: La Salvia A, Barroso G, Espinosa Olarte P, Anton Pascual B, Modrego Sanchez A,

Keywords: molecular profiling, neuroendocrine neoplasm, TMB, microsatellite instability (MSI)/mismatch repair deficiency (MMRd) status, prognosis,

#2895 Survival Related to Treatment of Patients with Metastatic Neuroendocrine Lung Tumors Treated in a Brazilian Center

Introduction: Well-differentiated Neuroendocrine Pulmonary Tumors (NETp) are morphologically classified as Typical (TC) and Atypical Carcinoid (AC).

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Tanaka H

Authors: Tanaka H, Petrocchi Corassa M, Carioca Freitas H, José de Barros e Silva M, Riechelmann R,

Keywords: Atypical Carcinoid, Typical Carcinoid, Neuroendocrine Pulmonary Tumors,

#2829 Everolimus-Induced Pneumonitis in Patients with Neuroendocrine Neoplasms: Multinational Study on Risk Factors and Outcomes

Introduction: The incidence and risk factors for everolimus-induced pneumonitis (EiP) have been poorly studied in patients (pts) with neuroendocrine neoplasms (NEN) outside of clinical trials.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Taboada R

Authors: Taboada R, Riechelmann R, Mauro C, Barros M, Hubner R,

Keywords: neuroendocrine, everolimus, pneumonitis,