miR-223 - A potential diagnostic biomarker in gastroenteropancreatic neuroendocrine tumors

#3194

Introduction: MicroRNAs (miRNAs) are key regulators of tumor biology, with functions that range from an oncogene to a tumor suppressor. They are proposed as diagnostic, prognostic and predictive circulating or tissue-based biomarkers in several human diseases, especially carcinoma. However, their role in pathogenesis of neuroendocrine neoplasia remains incompletely elucidated, and emerging insights still await translation into clinical treatment modalities.

Aim(s): The present study investigates proliferation-related miRNA miR-21 and immune-related miRNA miR-223 in respect to their potential role as a diagnostic and prognostic biomarker in serum of neuroendocrine tumor (NET) patients.

Materials and methods: We analysed circulating levels of miR-21 and miR-223 using semi-quantitative reverse-transcriptase PCR in 45 serum samples from patients with gastroenteropancreatic NET treated between 2010 and 2019 at our institution in comparison to healthy controls. Results were linked to clinical data, including proliferation activity according to Ki-67 index, tumor grading, TNM stage, somatostatin receptor expression, presence of functional disease or tumor relapse.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Özdirik B, Mohr R, Geisler L, Tacke F, Jann H,

Keywords: miR-21, miR-223, gastroenteropancreatic, neuroendocrine tumor, diagnostic, biomarker,