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#3078 Gastroenteropancreatic Neuroendocrine Tumor: Experience of an Algerian Centre
Introduction: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NETs) constitute a rare and heterogeneous group of tumors and still constitute a diagnostic and therapeutic challenge.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Keywords: gastroenteropancreatic neuroendocrine tumor, centre experience, treatment, survival,
Introduction: Atypical carcinoid and small cell lung cancer (SCLC) are currently incurable. There is thus a critical need for new diagnostic and therapeutic strategies for lung neuroendocrine neoplasms (LNEN). Chemokine receptor 4 (CXCR4), a G protein coupled receptor and theranostic target, plays a crucial role in metastases of LNEN. We hypothesize combination of thioredoxin reductase (TR) inhibitor represents a metabolic strategy to enhance cytotoxicity in peptide-receptor radionuclide therapy (PRRT) of LNEN.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Liu D
Authors: Liu D, Fath M, Robles Planells C, Balk E, Bellizzi A,
Keywords: CXCR4, thioredoxin reductase inhibitor, theranostics, atypical carcinoid, small cell lung cancer,
Introduction: The presence of nodal metastasis is one of the most important predictive factors for recurrence after radical surgery for nonfunctioning Pancreatic Neuroendocrine Neoplasms (NF-PanNEN). Nevertheless, it is not clear which is the best diagnostic examination to identify preoperatively lymphnodal metastasis.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Giannone F
Authors: Giannone F, Muffatti F, Partelli S, Andreasi V, Guarneri G,
Keywords: imaging, lymph node, metastases,
Introduction: Peptide receptor targeting has proven to be a pivotal tool for diagnostic imaging and radioligand therapy of neuroendocrine neoplasms (NENs), which frequently express somatostatin receptors (SSTRs) on their cell surface. However, up to 30 % of NEN patients do not benefit from SSTR-based approaches, others develop a resistance.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Grötzinger C, Exner S, Schuldt C, Du J, Sachindra S,
Keywords: receptor, targeting, imaging, prrt, peptide, angiotensin,
Introduction: Small intestinal neuroendocrine tumours (SI-NETs) represent a heterogenous group of tumours. The molecular mechanisms which contribute to progression of SI-NETs are poorly elucidated. They are considered to be molecularly distinct from neuroendocrine carcinomas (NECs), which share oncogenic pathways with adenocarcinomas.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Samsom K
Authors: Samsom K, van Veenendaal L, Roepman P, Kodach L, Steeghs N,
Keywords: whole genome sequencing, neuroendocrine tumour, small intestine, genetics,