#3240
miR-29b serum levels are down-regulated in patients with neuroendocrine tumors
Introduction:
Due to its involvement in tumor biology as well as tumor-associated stroma cell responses, recent data suggested a potential role of miR-29 as a biomarker for different malignancies.
Conference:
18th Annual ENETS Concerence (2021)
Presenting Author:
Roderburg C
Authors:
Özdirik B,
Mohr R,
Jann H,
Geisler L,
Tacke F,
Keywords:
neuroendocrine tumor,
miRNA,
miR-29,
prognosis,
biomarker,
#3237
Soluble urokinase Plasminogen Activator Receptor (suPAR) serum levels are elevated in patients with neuroendocrine neoplasia
Introduction:
Neuroendocrine neoplasia (NEN) represent a heterogeneous group of malignancies that might be challenging to diagnose. In case of advanced disease stages and especially in cases of poorly differentiated (G3) NEN, patients face a dismal prognosis. Therefore, innovative biomarkers allowing an early diagnosis as well as an optimal selection of suitable treatment options might help to improve clinical management of these patients.
Conference:
18th Annual ENETS Concerence (2021)
Presenting Author:
Roderburg C
Authors:
Burcin �,
Mohr R,
Jann H,
Geisler L,
Tacke F,
Keywords:
suPAR,
neuroendocrine tumor,
biomarker,
prognosis,
#3224
MicroRNAs - 193 and -223 alter NET differentiation markers and shape inflammatory response in vitro
Introduction:
Future improvements in NETs therapy depend on treatments tailored to tumor cell characteristics, microenvironment and inflammatory status. We recently reported selective downregulation of microRNAs (miRs) -29 and -223 in serum of NET patients, suggesting a possible role in NET disease.
Conference:
18th Annual ENETS Concerence (2021)
Presenting Author:
Authors:
Geisler L,
Özdirik B,
Mohr R,
Knorr J,
Tacke F,
Keywords:
miR,
NET,
BON,
in vitro,
biomarker,
inflammation,
#3194
miR-223 - A potential diagnostic biomarker in gastroenteropancreatic neuroendocrine tumors
Introduction:
MicroRNAs (miRNAs) are key regulators of tumor biology, with functions that range from an oncogene to a tumor suppressor. They are proposed as diagnostic, prognostic and predictive circulating or tissue-based biomarkers in several human diseases, especially carcinoma. However, their role in pathogenesis of neuroendocrine neoplasia remains incompletely elucidated, and emerging insights still await translation into clinical treatment modalities.
Conference:
18th Annual ENETS Concerence (2021)
Presenting Author:
Authors:
Özdirik B,
Mohr R,
Geisler L,
Tacke F,
Jann H,
Keywords:
miR-21,
miR-223,
gastroenteropancreatic,
neuroendocrine tumor,
diagnostic,
biomarker,
