Molecular characterization of a multi-institutional pan-lung cohort using integrative genomic and transcriptomic analysis

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Introduction: Lung cancer represents one of the most common neoplasm worldwide and leading cause of cancer mortality. World Health Organization (WHO) show six major histotypes (AC, LCNEC, SCLC, TC, ADC, SQC) dividing them mainly in two lineages (neuroendocrine and non-neuroendocrine) that can also combine each other.

Aim(s): Molecular analysis on revised large multicenter series of lung cancers may be able to provide more appropriate diagnostic indications and develop new and personalized therapeutic approaches.

Materials and methods: A retrospective series (1978-2019) collected from five Italian institutions of more than 600 surgically resected primary lung cancers were centrally reviewed and reclassified according to WHO 2015 criteria. Direct comparison among subtypes were performed by applying an genomic and transcriptomic analysis.

Conference:

Presenting Author:

Authors: Simbolo M, Centonze G, Giudice L, Ali G, Ciaparrone C,

Keywords: neuroendocrine carcinoma, next generation sequencing, transcriptomics, lung cancer, combined-lung cancer,