Prognostic and predictive value of baseline neutrophil-lymphocyte ratio and its variations after adjuvant radiotherapy in locally advanced Merkel Cell Carcinoma (MCC)

#3153

Introduction: High baseline neutrophil-lymphocyte ratio (H-NLR) ≥ 3.5 was shown to be a negative prognostic factor in solid cancers including MCC. Prognostic and predictive impact of adjuvant radiotherapy (RT)-Induced NLR variations are unknown.

Aim(s): The present study explores the prognostic and predictive role of baseline NLR and its variations RT in stage II-III MCC patients (pts).

Materials and methods: In our Institution (period 2004-2019), we retrospectively identified 95 pts (with Cooperative Oncology Group Performance Status 0 or 1 and negative for infective/autoimmune diseases or for immunomodulant drugs) who underwent radical surgery for stage II-III MCC. We collected NLR values at diagnosis (baseline), within one month before RT start, within one month after RT completion.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Torchio M

Authors: Torchio M, Corti F, Prinzi N, Manca P, Cattaneo L,

Keywords: merkel cell carcinoma, neutrophil-lymphocite ratio, biomarker,