Abstract Library

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#3246 Baseline albumin and neutrophil-to-lymphocyte ratio as predictive biomarkers of response to platinum-based therapy in patients with highly proliferative neuroendocrine carcinomas

Introduction: Neuroendocrine carcinomas (NECs) with ki-67/MIB1>55% show different responses to platinum-based therapy. Loss of Rb protein and KRAS mutation are markers of response, but it is unknown whether also clinical factors may have a predictive role.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Colombo E

Authors: Colombo E, Manca P, Prinzi N, Torchio M, Corti F,

Keywords: neuroendocrine carcinoma, albumin, neutrophil-to-lymphocyte ratio, neutropenia, platinum-based therapy, predictive biomarker, clinical biomarker, NECs,

#3153 Prognostic and predictive value of baseline neutrophil-lymphocyte ratio and its variations after adjuvant radiotherapy in locally advanced Merkel Cell Carcinoma (MCC)

Introduction: High baseline neutrophil-lymphocyte ratio (H-NLR) ≥ 3.5 was shown to be a negative prognostic factor in solid cancers including MCC. Prognostic and predictive impact of adjuvant radiotherapy (RT)-Induced NLR variations are unknown.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Torchio M

Authors: Torchio M, Corti F, Prinzi N, Manca P, Cattaneo L,

Keywords: merkel cell carcinoma, neutrophil-lymphocite ratio, biomarker,

#2716 Neuroendocrine Carcinoma of the Upper Urinary Tract: A Case Report

Introduction: There are no dedicated guidelines for treatment of urothelial NEC given disease rarity. An aggressive approach, including neoadjuvant cisplatin-based chemotherapy + nephroureterectomy and adjuvant platinum-based chemotherapy, is recommended.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Rossi R

Authors: Rossi R, Monteleone M, Altomare M, Torchio M, Pusceddu S,

Keywords: Urothelial neuroendocrine carcinoma, chemotherapy, surgery, radiotherapy,