Prospective analysis of the risk of post-surgical recurrence in lung typical carcinoid

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Introduction: In localized/locally advanced forms of NET, radical surgical resection represents the standard of care.

Aim(s): The aim of this prospective observational study was to evaluate recurrence-free survival (RFS) and the predictive role of clinical-pathological factors in typical lung carcinoid.

Materials and methods: Patients with localized/locally advanced typical carcinoid, undergoing radical surgery and with at least 1 year of post-operative follow-up, referred to our ENETS Outpatient Clinic (01/21-10/23), were evaluated. The following factors were considered: a) clinical parameters: age, sex, TNM, lymphnode, mitotic index, Ki-67, site, side; b) immunohistochemical markers: CD56, Synaptophysin, Chromogranin A, TTF-1, and CKAE1/AE3; c) circulating markers: CgA, NSE, urinary 5-HIAA. RFS was calculated with Kaplan-Mayer analysis, and the role of prognostic factors was assessed using log-rank test.

Conference:

Presenting Author:

Authors: Paravani P, Russo F, Mazzilli R, Zamponi V, Mancini C,

Keywords: Lung typical carcinoid, recurrence-free-survival, Ki-67%, Male sex, Mitotic Index, TTF-1, Surgery,