Real-world data regarding the obesity paradox in patients with gastroenteropancreatic (GEP) NENs in a single centre in the United Kingdom

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Introduction: The obesity paradox is a hypothesis showing patients (pts) with obesity have a prolonged overall survival compared to the ones with a normal weight. This paradox is present in multiple types of gastrointestinal cancer. In one population-based study from the USA, this paradox is also present in pts with GEP-NENs. However real-world data for the UK are lacking.

Aim(s): To explore the presence of the obesity paradox in a real-life cohort of pts with GEP-NENs.

Materials and methods: A cross-sectional study was performed regarding all pts with GEP-NENs and treatment with monthly somatostatin analogues (SSA’s) between Aug 2018 and Feb 2019. Demographic, histopathologic and anthropometric data were collected. Overall survival (OS) was calculated from the moment of screening until death or the last follow-up appointment. Kaplan Meier, log-rank tests, cox regression analysis were performed.

Conference:

Presenting Author: Clement D

Authors: Clement D, Brown S, Dolly S, Kibriya N, Howard M,

Keywords: gep-nen, survival, bmi, obesity paradox,