Results of NETest liquid biopsy in high-grade gastroenteropancreatic neuroendocrine neoplasms

#3717

Introduction: Molecular blood biomarkers are lacking for high-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN), and morphologically separating between neuroendocrine carcinoma (NEC), neuroendocrine tumors (NET G3), adenocarcinoma and MINEN frequently difficult. The mRNA-based NETest has diagnostic, prognostic and predictive value in neuroendocrine tumors G1-2 but has not been studied in HG GEP-NEN.

Aim(s): NETest measurements in HG GEP-NEN.

Materials and methods: Patients with advanced HG GEP-NEN were prospectively included. A blood sample was collected before the start of chemotherapy, blinded and NETest was measured. Final results are expressed as an activity index (NETest score) from 0 to 100. The normal score cut-off is 20. Histological sections were blinded before centralized pathological re-evaluation.

Conference:

Presenting Author: Sorbye H

Authors: Sorbye H, Langer S, Hjortland G, Vestermark L, Sundlov A,

Keywords: NETest, high-grade, gastroenteropancreatic, neuroendocrine carcinoma, NET G3, neuroendocrine neoplasm, biomarker,