Surgical and Survival Outcomes of Early Peptide Receptor Radionuclide Therapy for Downstaging Locally Advanced or Oligometastatic Pancreatic Neuroendocrine Neoplasms

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Introduction: Pancreatic neuroendocrine neoplasm (pNEN) patients often present with locally advanced or metastatic disease. The objective response rate of peptide receptor radionuclide therapy (PRRT) in pNENs is 55%. Therefore, PRRT may be a possibility for patients who are not eligible for upfront curative surgery.

Aim(s): To assess the potency of PRRT to render locally advanced or oligometastatic pNENs resectable and to evaluate the effect of surgery after early PRRT on survival.

Materials and methods: A single-center retrospective analysis was performed on 50 pNEN patients, treated between 2000 and 2019 with 177Lu-DOTATATE with a neoadjuvant or downstaging intent. Patients had borderline resectable or unresectable locoregional disease and/or metastatic disease.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Minczeles N, van Eijck C, van Gils M, van Velthuysen M, Nieveen van Dijkum E,

Keywords: neoadjuvant, peptide receptor radionuclide therapy, neuroendocrine, pancreas, surgery,