Whole Exome Sequencing Reveals the Monoclonal Origin of Gastric Mixed Adenoneuroendocrine Carcinomas
Introduction: Gastric mixed adenoneuroendocrine carcinomas (g-MANECs) are rare neoplasms consisting of adenocarcinoma and neuroendocrine neoplastic components. G-MANECs show more malignant characteristics than gastric adenocarcinomas, while molecular mechanisms underlying the co-existence of the two components remains unknown.
Aim(s): The study aims to investigate the origin and evolution of g-MANECs using whole exome sequencing analyses.
Materials and methods: The adenocarcinoma and neuroendocrine components from 20 patients with g-MANECs were microdissected and the whole exome sequencing analyses of the two components were performed separately.
Conference: 17th Annual ENETSConcerence (2020)
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